منابع مشابه
Information transfer between duplicated chromosomal sequences in mammalian cells involves contiguous regions of DNA.
We have investigated the nature of information transfer that appears to occur nonreciprocally between duplicated chromosomal sequences in cultured mouse L cells. We have studied gene conversion between two different defective thymidine kinase genes derived from two closely related strains of type 1 herpes simplex virus and that share a silent restriction site polymorphism. Our results demonstra...
متن کاملCross-Talk and Information Transfer in Mammalian and Bacterial Signaling
In mammalian and bacterial cells simple phosphorylation circuits play an important role in signaling. Bacteria have hundreds of two-component signaling systems that involve phosphotransfer between a receptor and a response regulator. In mammalian cells a similar pathway is the TGF-beta pathway, where extracellular TGF-beta ligands activate cell surface receptors that phosphorylate Smad proteins...
متن کاملIsoaccepting transfer RNA's in mammalian differentiated cells and tumor tissues.
amino acids derived from the MOPC 31C plasma cell tumor and resolved by the RPC-2 column chromatography was published (28). Except for tryptophan, multiple peaks of isoaccepting tRNA were observed for each of the other 19 amino acids, each having its characteristic elution pattern. As compared to E. coli studied under similar Chromatographie conditions (24), MOPC 31C plasma cell tumors showed v...
متن کاملTransfer and expression of foreign genes in mammalian cells.
The transfer of foreign genes into eukaryotic cells, in particular mammalian cells, has been essential to our understanding of the functional significance of genes and regulatory sequences as well as the development of gene therapy strategies. To this end, different mammalian expression vector systems have been designed. The choice of a particular expression system depends on the nature and pur...
متن کاملSystematic Transfer of Prokaryotic Sensors and Circuits to Mammalian Cells
Prokaryotic regulatory proteins respond to diverse signals and represent a rich resource for building synthetic sensors and circuits. The TetR family contains >10(5) members that use a simple mechanism to respond to stimuli and bind distinct DNA operators. We present a platform that enables the transfer of these regulators to mammalian cells, which is demonstrated using human embryonic kidney (...
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ژورنال
عنوان ژورنال: Nature
سال: 1975
ISSN: 0028-0836,1476-4687
DOI: 10.1038/257443a0